Prevalence, human leukocyte antigen typing and strategy for screening among Asian first-degree relatives of children with celiac disease
نویسندگان
چکیده
منابع مشابه
Celiac disease in first degree relatives of celiac children.
CONTEXT The first degree relatives of celiac patients represent a high risk group for the development of this disorder, so their screening may be crucial in the prevention of long-term complications. OBJECTIVE In order to determine the prevalence of celiac disease in a group of first degree relatives of children with proven gluten intolerance, we conducted a prospective study that consisted i...
متن کاملPrevalence of celiac disease among first degree relatives of Brazilian celiac patients.
BACKGROUND Several studies have shown that celiac disease, an autoimmune disorder that occurs in genetically susceptible individuals, is highly prevalent among relatives of celiac patients. AIM To determine the prevalence of celiac disease in a group of first degree relatives of Brazilian celiac patients. METHODS First degree relatives of celiac patients attending the Brasilia University Ho...
متن کاملSerologic screening and genetic testing among brazilian patients with celiac disease and their first degree relatives.
CONTEXT Celiac disease susceptibility has been shown to be associated with the HLA alleles DQA1*0501 and DQB1*0201 (together encoding the DQ2 heterodimer) that are present in practically all celiac disease patients. The DQ8 heterodimer (coded by DQA1*03-DQB1*0302), which is carried on a DRB1*04 (DR4) haplotype, is commonly encoded for by the few celiacs who do not carry the DQ2 heterodimer. Onl...
متن کاملCeliac disease in children from Madeira island and its prevalence in first degree relatives.
CONTEXT It is well recognized that celiac disease is an immune-mediated systemic disorder highly prevalent among relatives of celiac patients. OBJECTIVES The aim of this study is to determine the prevalence of celiac disease in a group of first degree relatives of celiac children, and to access the frequency of human leukocyte antigen HLA-DQ2 and DQ8 in celiac disease patients and their affec...
متن کاملAutoantibody and human leukocyte antigen profiles in children with autoimmune liver disease and their first-degree relatives.
OBJECTIVE Familial clustering of juvenile autoimmune liver disease (AILD), including autoimmune hepatitis and autoimmune sclerosing cholangitis (ASC), is rare, despite a high prevalence of autoimmune disorders in AILD families. METHODS To investigate this discrepancy, we measured autoantibodies diagnostic for AILD, anti-nuclear, anti-smooth muscle, anti-liver kidney microsomal type 1, anti-li...
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ژورنال
عنوان ژورنال: Journal of Gastroenterology and Hepatology
سال: 2010
ISSN: 0815-9319,1440-1746
DOI: 10.1111/j.1440-1746.2009.06044.x